(1. 山東科技大學(xué) 材料科學(xué)與工程學(xué)院，青島 266590
2. 山東科技大學(xué) 化學(xué)與生物工程學(xué)院，青島 266590)
摘 要: 近年來，生物可降解植入材料的應(yīng)用發(fā)展迅速，其中鎂及合金因其具有良好的生物相容性與生物可降解性，成為新一代具有廣闊發(fā)展前景的生物醫(yī)用可降解金屬材料，但存在鎂合金本身由于快速腐蝕釋放鎂離子使周圍環(huán)境堿化而具有的抗菌性和骨植入物需要長期保持力學(xué)性能之間的矛盾。本文總結(jié)了多種類型的金屬及其氧化物、生物活性物質(zhì)、天然抗菌物質(zhì)、光熱、光動力療法在抗菌鎂合金及表面抗菌涂層領(lǐng)域的研究進(jìn)展，研究多種鎂合金表面耐蝕抗菌涂層的制備方法，重點(diǎn)討論了不同抗菌載體對鎂合金耐蝕抗菌性的影響。結(jié)果表明：現(xiàn)階段抗菌鎂合金設(shè)計、鎂合金抗菌耐蝕涂層制備的研究逐漸成熟，但也存在一些亟需解決的問題。同時，綜合闡述了生物醫(yī)用可降解鎂合金表面抗菌涂層未來的發(fā)展方向。
關(guān)鍵字: 鎂合金；抗菌性；涂層；生物材料
（1. College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China;
2. College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China）
Abstract:In recent years, the application of biodegradable implant materials has a fast development. Magnesium (Mg) and its alloys have become a new generation of biodegradable metal materials with broad prospects due to their good biocompatibility and biodegradability. However, the contradiction between the antibacterial properties, resulted from the releasing of Mg2+ ions and the alkalization of the surrounding environment in the process of rapid corrosion, and the long-term mechanical properties as the bone implants needs to be resolved urgently. This paper summarized the research progress of various metals and its oxides, biologically active substances, natural antibacterial substances and photothermal and photodynamic therapy on antibacterial Mg alloys and antibacterial coatings on the surface of Mg alloys. The preparation methods of various corrosion-resistant and antibacterial coatings on the surface of Mg alloys were studied, and the influence of different antibacterial carriers on the corrosion resistance and antibacterial activity of Mg alloys was discussed. The results show that the evolution of antibacterial Mg alloys and antibacterial coatings on the surface of Mg alloys are gradually matured, but there still are some problems need to be solved. Finally, the way forward of the antibacterial coating on the surface of biomedical degradable Mg alloys is elaborated.
Key words: magnesium alloys; antibacterial property; coating; biomaterials
