(1. 中南大學(xué) 材料科學(xué)與工程學(xué)院，有色金屬材料科學(xué)與工程教育部重點(diǎn)實(shí)驗(yàn)室，長沙 410083； 2. 吉林大學(xué) 第二醫(yī)院骨科，長春 130041)
摘 要: 以3D打印技術(shù)制備的多孔Ti6Al4V鈦合金支架為研究對象，研究其顯微結(jié)構(gòu)特征與力學(xué)性能的關(guān)系，利用骨髓間充質(zhì)干細(xì)胞研究多孔鈦合金支架的生物相容性，以及在家兔全層骨缺損模型中研究支架周圍骨質(zhì)的生長情況。結(jié)果表明：3D打印的多孔Ti6Al4V鈦合金支架的力學(xué)性能受其多孔特性的影響，具有較適合人體需求的初始強(qiáng)度；同時(shí)材料具有良好的細(xì)胞生物相容性；且多孔支架中的立體網(wǎng)格結(jié)構(gòu)為細(xì)胞提供了生長空間，增加了骨髓間充質(zhì)干細(xì)胞的增殖能力，促進(jìn)了鈦合金支架微孔中骨組織長入的速度。
關(guān)鍵字: Ti6Al4V多孔支架；3D打印；力學(xué)性能；骨髓間充質(zhì)干細(xì)胞；骨長入；生物相容性
（1. School of Materials Science and Engineering, Key Laboratory of Nonferrous Metal Materials Science and Engineering, Ministry of Education, Central South University, Changsha 410083, China; 2. Department of Orthopedics, The Second Hospital, Jilin University, Changchun 130041, China）
Abstract:Taking titanium alloy Ti6Al4V porous scaffolds by 3D printing as research object, the relationship between the microstructure characteristics and the mechanical properties was preliminarily investigated. Moreover, the bone marrow mesenchymal stem cells were used to investigate the biological compatibility, and the in vivo bone ingrowth ability of the Ti6Al4V porous scaffolds in a rabbit full-thickness bone defect model was detected. The results show that the mechanical properties of Ti6Al4V porous scaffolds prepared by 3D printing are affected by the porous microstructures with the incipient intensity that is suitable for human body. The Ti6Al4V porous scaffolds also have good biocompatibility and absorbability. The detailed grid structure in Ti6Al4V porous scaffolds provides a unique space for cells to grow, which can increase the proliferative ability of the bone marrow mesenchymal stem cells, and promote the ingrowth speed of the surrounding bone tissue in prosthetic microporous.
Key words: Ti6Al4V porous scaffold; 3D printing; mechanical property; bone marrow mesenchymal stem cell; bone ingrowth; biocompatibility
