Abstract:A novel antibacterial biomimetic porous titanium implant with good osseointegration was prepared by freeze-casting and thermal oxidation. Bone integration properties of the porous titanium implant were evaluated by cell proliferation assay, alkaline phosphatase activity assay, X-ray examination and hard bone tissue biopsy. The in vitro cell proliferation and the level of differentiation of the group with a modified nano-porous implant surface were significantly higher than those in the group without surface modification and the dense titanium control group (P<0.05). In vivo, bone growth and osteogenesis were found in the experimental groups with modified and unmodified porous titanium implants; osteoblasts in the modified group had more mature differentiation in the pores compared to the unmodified group. Such implants can form solid, biologically compatible bone grafts with bone tissues, exhibiting good osseointegration.

Key words: antibacterial function; surface modification; porous titanium implant; osseointegration; freeze-casting