中國(guó)有色金屬學(xué)報(bào)(英文版)
Transactions of Nonferrous Metals Society of China
| Vol. 23 No. 11 November 2013 |
（1. The Third Xiangya Hospital, Central South University, Changsha 410013, China;
2. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China;
3. The Affiliated Tumor Hospital of Xiangya Medical School of Central South University, Changsha 410013, China;
4. Institute of Pain Medicine, Central South University, Changsha 410013, China）
Abstract:The cytotoxicities of single-walled carbon nanotubes (SWNTs) and acid purified single-walled carbon nanotubes (SWNT-COOH) were investigated by spectroscopic analysis. Cell viability and cell apoptosis were applied to assessing the cytotoxicity of SWNT-COOH, cetyltrimethyl ammonium bromide (CTAB) and acid purified carbon nanotubes modified with cetyltrimethyl ammonium bromide (SWNT-COOH/CTAB). The results indicate that SWNTs are more toxic than SWNT-COOH. Concentration and time-curve analyses indicate that cytotoxicity of SWNT-COOH/CTAB is more related to the toxicity of the surfactant CTAB. The cytotoxicity effect of CTAB and SWNT-COOH/CTAB is acceptable at low concentrations (0.5-25 μg/mL). The cytotoxicity observation suggests that SWNT-COOH/CTAB can safely applied to biomedical field at low concentrations (0.5-25 μg/mL).
Key words: single-walled carbon nanotube; cetyltrimethyl ammonium bromide; cytotoxicity; acid purification; apoptosis
