(1. 上海交通大學 材料科學與工程學院 輕合金精密成型國家工程研究中心，上海 200240；
2. 上海交通大學 附屬第三人民醫(yī)院骨科，上海 201900；
3. 上海交通大學 附屬第六人民醫(yī)院骨科，上海 200233)
摘 要: 鎂合金因具有與人體骨頭接近的密度和彈性模量、高比強度和比剛度、生物可降解性以及生物相容性等優(yōu)點，近10年來國內外研究人員對其應用于骨內植物、骨組織工程支架和心血管支架等領域進行了廣泛的研究。然而，目前大多數(shù)研究均以現(xiàn)有商用鎂合金為對象，如含Al元素的AZ31、AZ91以及含重稀土元素的WE43等，并未考慮到作為生物材料的安全性等問題。本文作者闡述鎂合金作為生物醫(yī)用材料的優(yōu)勢、面臨的挑戰(zhàn)以及應對策略；重點介紹上海交通大學輕合金精密成型國家工程研究中心近年來圍繞自行研發(fā)的新型生物醫(yī)用鎂合金JDBM開展的研究工作；最后展望可降解生物醫(yī)用鎂合金的應用前景和發(fā)展方向。
關鍵字: 可降解生物醫(yī)用鎂合金；骨內植物；心血管支架；生物相容性；生物降解性能
biomedical magnesium alloys JDBM
HE Yao-hua3, JIANG Yao3, DING Wen-jiang
（1. National Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering,
Shanghai Jiao Tong University, Shanghai 200240, China;
2. Department of Orthopedics, the Third People’s Hospital Affiliated to Medical College,
Shanghai Jiao Tong University, Shanghai 201900, China;
3. Department of Orthopedics, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University,
Shanghai 200233, China）
Abstract:Mg alloys have been extensively studied in the last decade in the fields of bone implants, bone tissue engineering scaffolds and cardiovascular stents due to their excellent properties, such as close density and elastic modulus to those of nature bone, high specific strength and rigidity, biodegradation and biocompatibility. However, most of the Mg alloys studied for biodegradable materials are aluminium-containing alloys, such as AZ31 and AZ91 and some heavy rare earth elements-containing alloys such as WE43. These alloys were originally developed for structural materials which did not consider the bio-safety as biomaterials. In this work, the advantages, challenges and strategies of the Mg alloys as biomedical materials are briefly introduced. The work on biomedical Mg alloys of the National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, is highlighted. Finally, the application prospects and direction of the biodegradable biomedical Mg alloys are prospected.
Key words: degradable biomedical magnesium alloys; bone implants; cardiovascular stents; biocompatibility; biodegradation properties
