周學(xué)東1，朱友家2，董維理2
(1.武漢理工大學(xué) 生物材料與工程研究中心，武漢 430070;
2.武漢大學(xué) 中南醫(yī)院，武漢 430072)
摘 要: α-TCP/TTCP骨水泥具有良好的水化硬化特性，符合臨床需要的凝結(jié)時(shí)間和抗壓強(qiáng)度，其水化產(chǎn)物主要為羥基磷灰石(HAP)。以α-TCP/TTCP骨水泥作為牙根管充填材料，通過體外實(shí)驗(yàn)、動(dòng)物實(shí)驗(yàn)，結(jié)合組織形態(tài)學(xué)及掃描電鏡觀察，檢測(cè)α-TCP/TTCP牙根管充填材料的組織相容性，并動(dòng)態(tài)觀察根尖閉合情況及根尖周組織修復(fù)過程。結(jié)果表明，材料具有優(yōu)良的生物相容性，在牙根管內(nèi)可繼續(xù)水化硬化，而且能引導(dǎo)根尖鈣化組織沉積，封閉根尖孔，形成骨性結(jié)合，并促進(jìn)根尖周組織愈合。
關(guān)鍵字: α-TCP/TTCP；牙根管充填；組織相容性；根尖孔閉合
filling material
LI Shi-pu1，ZHOU Xue-dong1，
ZHU You-jia2，DONG Wei-li2
（1.Biomedical Materials and Engineering Center，
Wuhan University of Technology，Wuhan 430070，China;
2.Zhongnan Hospital，Wuhan University，
Wuhan 430072，China）
Abstract:A root canal filling material was obtained by mixing α-tricalcium phosphate，tetracalcium phosphate and additives with an aqueous solution containing three carbonyl groups. Powder and liquid were mixed at ratio of 1.25g/mL. This material has good hydration characteristic，appropriate setting time and compressive strength，which accords with the desire of clinic. The biocompatibility of this material was investigated primarily by in vitro test and animal experiments. The α-TCP/TTCP cement was used to fill adult dogs' root canal，the effects of the material on the apical closure，restoration of periapical tissues and adaptability to the dentinal surface were observed by histomorphology and SEM. The results show that α-TCP/TTCP composite cement has excellent biocompatibility with soft and hard tissues，it hydrates and hardens continually in root canal.Its osteoconductivity can promote the formation of calcific barriers and healing of periapicaltissue. The apex can be closed completely.
Key words: α-TCP/T, TCP cement；root canal filling；histocompatibility；apical closure
