(武漢理工大學(xué)生物材料與工程研究中心, 武漢 430070)
摘 要: 探討細(xì)胞對(duì)可降解多孔磷酸三鈣陶瓷（β-TCP）降解的影響及材料骨內(nèi)植入后在體內(nèi)超微結(jié)構(gòu)的變化，研究了磷酸三鈣陶瓷的生物降解、 新骨生成過(guò)程及結(jié)構(gòu)的變化， 為可降解鈣磷材料的生物降解和骨生成機(jī)制提供依據(jù)。 研究結(jié)果表明， 材料在體內(nèi)超微結(jié)構(gòu)的變化是影響材料降解的重要因素之一；鈣磷材料通過(guò)溶解沉積參與新骨形成， 以O(shè)CP， DOHA和HAP的形式存在于骨膠原纖維中，與其他有機(jī)質(zhì)一起構(gòu)成新骨。
關(guān)鍵字: 磷酸三鈣陶瓷; 生物降解; 超微結(jié)構(gòu); 參與; 新骨形成
SHEN Chun-hua, JIANG Xin
（Biomedical Materials and Engineering Center,
Wuhan University of Technology,
Wuhan 430070, China）
Abstract:The effect of cells on the biodegradation of porous tricalcium phosphate (β-TCP) and the ultrastructure transformation of the materials after implantation were studied. The process of biodegradation, new-bone formation and structural change of calcium phosphate ceramics were also investigated. The results provide the direct evidence of the mechanism of biodegradation and osteogenesis for biodegradable calcium-phosphor (Ca-P) ceramics, and show that the ultrastructural transformation of Ca-P in vivo is one of the important factors of biodegradation. No-life Ca-P materials participate in new-bon formation by force of dissolution and deposition. It constitutes bone tissue with other organics together in the form of OCP, DOHA and HAP, which consist in osteocollagenous fibers.
Key words: calcium phosphate ceramics; biodegradation; ultrastructure; participation; bone formation
