(1. 中國科學(xué)院 金屬研究所，沈陽 110016;
2. 中國科學(xué)院 研究生院，北京 100864)
摘 要: 采用浸涂法制備Mg植入材料表面聚乳酸涂層，通過選擇不同相對(duì)分子質(zhì)量的聚乳酸并采用硅烷偶聯(lián)劑對(duì)Mg植入材料表面進(jìn)行預(yù)處理，提高Mg植入材料與聚乳酸的結(jié)合力。利用掃描電鏡得出浸涂時(shí)間、聚合物濃度及浸涂次數(shù)對(duì)涂層厚度的影響。發(fā)現(xiàn)Mg植入材料表面涂覆相對(duì)分子質(zhì)量為20萬的聚(乳酸−羥基乙酸)能夠滿足降解條件和結(jié)合力的要求。經(jīng)聚乳酸表面處理的試樣在Hank’s 溶液中浸泡10 d后，計(jì)算試樣質(zhì)量損失，發(fā)現(xiàn)表面處理后的試樣質(zhì)量損失明顯降低。實(shí)驗(yàn)表明，鎂表面涂覆聚乳酸涂層，可以有效提高其在模擬體液中的耐蝕性。
關(guān)鍵字: 浸涂；Mg植入材料；結(jié)合力；耐蝕性
（1. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;
2. Graduate School of Chinese Academy of Sciences, Beijing 100864, China）
Abstract:To be an implant material, it is necessary to have good corrosion resistance for magnesium and magnesium alloy in the period of tissue healing process. To improve corrosion resistance of pure magnesium, dipping technology was employed in the present work to prepare the poly (lactic acid) coating on Mg implant. Different molecular mass poly (lactic acid) and a surface pretreatment technology applying silane coupling agents on Mg implant was used to improve adhesion strength between Mg implant and poly lactic acid. Scanning electron microscopy (SEM) was used to gain the effect of dipping time, polymer concentration and dipping times for the thickness of coating. The results show that poly (DL-lactide-co-glycolide) (PLGA) with relative molecular mass of 200 thousand can meet the need of degradation condition and strength adhesion of biodegradable implant. The mass loss of PLGA film coated Mg implant is decreased obviously after they are immersed in Hank’s solution. It can be concluded that PLGA coating can effectively protect magnesium from corrosion in simulation biology solution.
Key words: dipping technology; Mg implant; adhesion strength; corrosion resistant
