中國有色金屬學(xué)報(英文版)
Transactions of Nonferrous Metals Society of China
| Vol. 14 No. 1 February 2004 |
XIONG Xian-li(熊先立)1, ZHENG Qi-xin(鄭啟新)2<
（1. Biomedical Materials and Engineering Research Center, Wuhan University of Technology,
Wuhan 430070, China;
2. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,
Wuhan 430022, China）
Abstract:The metabolic way of calcium ions which was released due to in vivo degradation of porousβ-TCP ceramics was studied by using the radioisotope45Ca as tracer. The result shows that some of the calcium ions enter blood and take part in the circulation. These calcium ions distribute into organs and tissues (such as liver, kidney, brain, heart, lung, spleen and stomach) and participate in the metabolisms of body. There is neither the accumulation of calcium ions, nor the lesion or pathologic calcification of the organs and tissues. Some of the calcium ions that enter the near-end femur, ulna and skull are reused by bony tissue to take part in both local mineralization processes during bone healing, or are stored in calcium pool which can participate in the whole body circulating. In the cyclical process, other calcium ions are excreted with urine and feces through kidney and liver. It is indicated that the degradation products of β-TCP ceramics can take part in the physiological metabolic process of normal bone and tissue.
Key words: β-TCP ceramics;45Ca tracing; metabolism; mineralization
